Neuro-Luminance ketamine treatment for depression is different from what other sites are doing. The difference is based upon understanding from research studies, as well as upon our extensive knowledge of pharmacology, neurobiology and neurophysiology.
It’s important to note that in research studies wherein patients received a single infusion only 60% of them got immediate benefit from the single infusion – meaning they felt better within hours or a day of treatment. Also, it is important to realize that these patents had been off all oral medications for several weeks before they received the single infusion of ketamine. In contrast, studies in which multiple infusions were given showed that only as few as 25% of patients noticed some improvement immediately. Thus, with a single infusion, a patient has a 25-60% chance of getting some immediate improvement or conversely, there is a 40-75% chance of noticing no difference with that single infusion. Therefore, Neuro-Luminance looks beyond immediate responses to long-term benefits for our patients.
We monitor the patient using a patient diary and also with follow-up clinic appointments either in person or by telephone. So the timing of further infusions is based upon how that individual patient is responding and the trajectory of response. We understand this process is different for each patient, so every patient has an individualized treatment plan based upon response after each infusion.Ketamine has two effects – the anesthesia effect which via the glycogen synthase kinase-3 pathway can have an almost immediate effect on mood, and the growth factor upregulation effect which reverses the neuronal damage that depression causes. It’s important to realize that depression causes brain damage with the loss of neurons, loss of dendrites and loss of synapses in the frontal cortex and the hippocampus. Neuro-Luminance uses ketamine to reverse these neuronal deficits. This is done when ketamine “sits on” or interacts with the NMDA receptors and in this way activates brain derived neurotrophic factor also known as BDNF, which begins the repair process by rebuilding synapses, inducing dendrites to form new branches, as well as triggering neurons to recover and form new circuits. There is evidence that ketamine causes specific stem cells to form new neurons.